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Molekulare Diagnostik

PentaBase

Wir führen die SensiScreen® Ready-to-use CE-IVD Assays von PentaBase.

Da unser Sortiment in diesem Bereich sehr komplex ist, zögern Sie bitte nicht uns zu kontaktieren!

 SEITE IST IM ENTSTEHEN - ASSAYS ARE SOON AVAILABLE!


Kategorien:

 Colo Rectal Cancer (CRC)

KRAS

NRAS

BRAF V600

  Lung Cancer (NSCLC)

EGFR

 Melanoma

BRAF V600

 

  SensiScreen instruction.pdf

  Quick guide Ready-to-use.pdf

There are two types of assays available:

  1. SensiScreen® Ready-to-use CE-IVD Assays: SensiScreen® Ready-to-use assays are pre-dispensed in PCR strips and require only addition of patient DNA for somatic mutation testing.
  2. SensiScreen® Dispense Ready CE-IVD Mixes: SensiScreen® Dispense Ready CE-IVD Mixes include all reagents for somatic mutation testing except plastic ware to be used with the real-time PCR system of choice.

Overview of mutations detected by SensiScreen®

SensiScreen® assays detect the most common somatic mutations present in KRAS, NRAS, BRAF and EGFR. Furthermore, a range of new assays is expected to be added to the portfolio in 2017.

 

NRAS mutations detected by SensiScreen®

Assay CDS mutation Amino acid mutation Cosmic ID
NRAS exon 2 c.35G>C Gly12Ala (G12A) COSM565
c.34G>T Gly12Cys (G12C) COSM562
c.35G>A Gly12Asp (G12D) COSM564
c.34G>C Gly12Arg (G12R) COSM561
c.34G>A Gly12Ser (G12S) COSM563
c.35G>T Gly12Val (G12V) COSM566
c.38G>C Gly13Ala (G13A) COSM575
c.37G>T Gly13Cys (G13C) COSM570
c.38G>A Gly13Asp (G13D) COSM573
c.37G>C Gly13Arg (G13R) COSM569
c.37G>A Gly13Ser (G13S) COSM571
c.38G>T Gly13Val (G13V) COSM574
NRAS exon 3 c.183A>T Gln61His (Q61H1) COSM585
c.183A>C Gln61His (Q61H2) COSM586
c.181C>A Gln61Lys (Q61K) COSM580
c.182A>T Gln61Leu (Q61L) COSM583
c.182A>G Gln61Arg (Q61R) COSM584
c.176C>A Ala59Asp (A59D) COSM253327
c.175G>A Ala59Thr (A59T) COSM578
NRAS exon 4 c.351G>C Lys117Asn (K117N1) N/A
c.351G>T Lys117Asn (K117N2) N/A
c.436G>C Ala146Pro (A146P) (COSM4172577)
c.436G>A Ala146Thr (A146T) COSM27174
c.437C>T Ala146Val (A146V) COSM4170228

ahn

brand

eppendorf

gilson

mettler toledo

heidolph

neolab

satorius

systec

thermo scientific

zeiss